Taffy Richardson
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Doxycycline is antibiotics widely used to treat Lyme ailment associated with erythema migrans. We conducted a two-part retrospective analysis of (1) the safety and efficacy of doxycycline compared with tetracycline and (2) the safety and niceness of a 14-day versus a 20-day course of doxycycline. Role of thiamphenicol in the treatment of community-acquired lung infectionsStreptococcus pneumoniae and Haemophilus influenzae are the two main pathogens responsible for bacterial respiratory tract infections. Their antimicrobial susceptibility to antibiotics like beta-lactams, macrolides or fluoroquinolones has been largely studied, while it remains less known to antibiotics other antibiotics like thiamphenicol, erythromycin, cotrimoxazole or tetracycline, often used in developing countries due to their availability. Pneumoniae strains were sensitive to thiamphenicol. Pneumoniae to erythromycin, cotrimoxazole and tetracycline was 70.9%, 83.9%, and 90.3% respectively. Influenzae and all Penicillin VK (V-Cillin K) susceptible S. Pneumoniae among which 69% had reduced susceptibility to Penicillin VK (V-Cillin K) (PRSP) and 87 H. The principal advantage of doxycycline over amoxicillin tetracycline for the treatment of Lyme disease associated with erythema migrans is the convenience of less frequent dosing, not enhanced efficacy or safety. Doxycycline versus tetracycline valtrex therapy for Lyme disease associated with erythema migrans.BACKGROUND. Influenzae isolates, 39.1% producing beta-lactamase, were recovered from sputum cultures in children. Susceptibility of Penicillin VK (V-Cillin K) sensitive S. Twenty-seven patients given tetracycline (500 mg four times a day for 14 days [group 1]) were compared retrospectively with 21 patients who received doxycycline (100 mg two or three times a day for 14 days [group 2]). Susceptibility of PRSP to thiamphenicol, erythromycin, cotrimoxazole and tetracycline was 68.1%, 7.2%, 17.4% and 44.9% respectively. The results for group 2 were also compared with that of 38 patients who received doxycycline for 20 days (100 mg three times daily) in a prospective treatment trial (group 3). There appears to be no advantage in extending treatment with doxycycline from 14 to 20 days.. There was no significant difference in the incidence of adverse drug effects or in efficacy at 1 month, but at 1 year there was a trend toward a better outcome in the group treated with tetracycline (p 0.08). However, thiamphenicol was better in detecting resistant organisms. A 14-day course of doxycycline was comparable to a 20-day course in the incidence of adverse drug effects and in clinical outcome. In this study, the activity of chloramphenicol and thiamphenicol on different respiratory tract pathogens was found to be equivalent. Thiamphenicol and chloramphenicol are still active against respiratory pathogens. Whether it is comparable to tetracycline is unknown.
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